MODIS-EVI

climate factors and meteorological drought index SPEI were used as the indicators to characterize the spatio-temporal changes of vegetation and climate

Theil-sen Median trend analysis

Mann-Kendall significance test

Hurst index analysis and residual analysis were used to explore the response of vegetation growth to climate change and human activities in Guizhou Province from 2001 to 2020. The results showed that:(1) The regional area ratio of vegetation increase in Guizhou Province from 2001 to 2020 was 84.97%

and the main improvement areas were mainly in the north and southwest of Guizhou Province. In terms of the future spatial change trend

vegetation was mainly in reverse continuous increasing

accounting for 69.23% of the total area of Guizhou Province. (2) There was a positive correlation between vegetation and precipitation and a negative correlation between vegetation and temperature in Guizhou Province

but the correlation was weak. While the positive correlation between regional vegetation growth and SPEI was greater than the negative correlation. (3) In the northern

western and southwestern regions of Guizhou Province

EVI and human activities showed positive improvement

while in Guiyang

Zunyi and its surrounding areas

EVI and human economic activities showed inhibitory effect. On the whole

there was a positive correlation between human economic activities and vegetation EVI in the study area. The conclusion could provide objective scientific theoretical support for the study of vegetation ecological protection and its suitability with climate change and human activities in Guizhou Province.